Improved methods of synthesis of valinomycins

✍ Scribed by Yves L. Dory; John M. Mellor; Jerome F. McAleer

• Book ID: 104229709
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 253 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)99557-1

✦ Synopsis

Linear depsipeptides have been efficiently cyclised to give cyclodepsipeptide valinomycin analogues via a protocol using activated pentafluorophenyl esters in conjunction with deprotection of a benzylcarbamate by in situ hydrogenolysis. Vallnomycins having a 36-membered ring could be obtained in up to 84% yield. Similar cyclisations affording 24-and 48-membered rings also are described.