Improved method for the assignment of the relative configuration of 1,3-diols, by using 13c-enriched acetonides
β Scribed by Antonio Trincone; Agata Gambacorta; Annunziata Soriente; Guido Sodano
- Book ID
- 108036219
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 151 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0957-4166
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Rychnovsky's recent correlation of the stereochemistry-dependent 13C NMR chemical shifts of 4,6-&substituted 13-diol acetonides with dial stereochemistry may be extended to more highly substituted dioxolanes bearing substituents in the Qosition. The 13C resonances of the acetonide carbons follow a p
An assignment of relative configurations has been achieved for the diastereomeric racernates(lR2R,lS2S) and (1R2S, 1S2R) of 3,3-dimethyl-l,2-diphenylbuta~-l-ol through the comparative analysis of the respective chemical shifts induced by Eu(fod), in the 'H and '"C NMR spectra, and the corresponding