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Improved MALDI-MS Analysis of Oligonucleotides through the Use of Fucose as a Matrix Additive

✍ Scribed by Distler, Anne M.; Allison, John

Book ID
119978600
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
48 KB
Volume
73
Category
Article
ISSN
0003-2700

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Cation adduction to oligonucleotides and nucleic acids during mass spectrometric analysis is a recurrent problem. We have found that the use of organic base solutions of high gas-phase proton affinity, as used previously in electrospray ionization mass spectrometry, can significantly reduce the cati