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Improved high-performance liquid chromatographic determination of pilocarpine and its degradation products in ophthalmic solutions importance of octadecylsilane column choice

✍ Scribed by Tony Y. Fan; G.Michael Wall; Kent Sternitzke; Lynn Bass; Angela B. Morton; Erik Muegge

Book ID: 107785993
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 478 KB
Volume: 740
Category: Article
ISSN: 1873-3778
DOI: 10.1016/0021-9673(96)00120-3

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## Abstract An ion‐pair high performance liquid chromatographic method was developed for the simultaneous determination of __p__‐aminosalicylic acid (PAS) and its degradation product __m__‐aminophenol (MAP) in a newly developed multiparticular drug delivery system. Owing to the concencentration dif