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Improved Heritability Estimation from Genome-wide SNPs

✍ Scribed by Doug Speed; Gibran Hemani; Michael R. Johnson; David J. Balding

Book ID
119184412
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
391 KB
Volume
91
Category
Article
ISSN
0002-9297

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Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantitative traits t