Genetic manipulation of mouse embryonic
β
Nicole Christ; Peter DrΓΆge
π
Article
π
2002
π
John Wiley and Sons
π
English
β 769 KB
## Abstract Summary: Mutant Ξ» integrases catalyze siteβspecific recombination reactions inside mammalian cells. Here we demonstrate that the integrase system can be used to eliminate resistance marker genes from the genome of mouse embryonic stem cells. Soβcalled integrative and excisive recombinat