To increase cationic liposome-mediated intravenous DNA delivery extruded DOTAP:cholesterol liposomes were used to form complexes with DNA, resulting in enhanced expression of the chloramphenicol acetyltransferase gene in most tissues examined. The DNA:liposome ratio, and mild sonication, heating, an
✦ LIBER ✦
Improved DNA: liposome complexes for increased systemic delivery and gene expression
✍ Scribed by Templeton, Nancy Smyth; Lasic, Danilo D.; Frederik, Peter M.; Strey, Helmut H.; Roberts, David D.; Pavlakis, George N.
- Book ID
- 109905753
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 905 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1087-0156
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