๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Improved detection of Duchenne muscular dystrophy heterozygotes using discriminant analysis of creatine kinase levels

โœ Scribed by Muir, W. A. ;Knoke, J. ;Martin, A. ;Vignos, P. ;McErlean, A. ;Opitz, John M.

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
534 KB
Volume
14
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

โœฆ Synopsis

We have assessed the sensitivity and specificity of tests to detect carriers of Duchenne muscular dystrophy by use of three serum enzymes (creatine kinase, pyruvate kinase, and aldolase) and discriminant analysis in 21 obligate heterozygotes and 28 normal controls. We found no significant age effects on enzyme levels. Each enzyme level considered separately was significantly higher in heterozygotes. Use of logs improved discrimination, and log CK was sufficient by itself as a discriminant (that is, addition of other enzymes did not significantly improve discrimination). We present procedures to generate posteriori probabilities for genetic counselling tbat incorporate prior probabilities and enzyme levels. Our results show both improved sensitivity (90%) and specificity (86%).

๐Ÿ“œ SIMILAR VOLUMES

Duchenne muscular dystrophy carrier dete
Duchenne muscular dystrophy carrier detection using logistic discrimination: Serum creatine kinase, hemopexin, pyruvate kinase, and lactate dehydrogenase in combination
โœ Percy, Maire E. ;Andrews, David F. ;Thompson, Margaret W. ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 710 KB

## Abstract In the absence of an unambiguous test for identifying Duchenne muscular dystrophy (DMD) heterozygotes, methods are needed for combination of the results of individually equivocal tests as effectively and rationally as possible. We used logistic discrimination to assess the effectiveness

Evaluation of carrier detection of Duche
Evaluation of carrier detection of Duchenne muscular dystrophy using carbonic anhydrase III and creatine kinase
โœ Heath, R. ;Carter, N. D. ;Jeffery, S. ;Edwards, R. J. ;Watts, D. C. ;Watts, R. L ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 308 KB ๐Ÿ‘ 2 views

Carbonic anhydrase III (CAIII) and creatine kinase (CK) were measured in plasma samples from a series of females at-risk as carriers of Duchenne muscular dystrophy and compared with control groups. Both plasma CAIII and CK levels were raised in a proportion of carriers. Although measurement of CAIII