Influence of selection criteria on mutat
โ
Karl Heinimann; Rodney J. Scott; Jean-Marie Buerstedde; Walter Weber; Karl Siebo
๐
Article
๐
1999
๐
John Wiley and Sons
๐
English
โ 109 KB
๐ 2 views
## BACKGROUND. Hereditary nonpolyposis colorectal cancer (HNPCC) is linked genetically to mutations in DNA mismatch repair (MMR) genes. Because a deficiency in MMR does not predict a specific phenotype, the original selection criteria may be too restrictive in identifying additional families. The