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Improved detection of anthelmintic activity in an in vitro screen utilizing adultNippostrongylus brasiliensis

โœ Scribed by E. B. Rapson; D. C. Jenkins; A. S. Chilwan


Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
191 KB
Volume
73
Category
Article
ISSN
1432-1955

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Optimizing pharmacokinetic properties to improve oral exposure is a common theme in modern drug discovery. In the present work, in vitro Caco-2 permeability and microsomal half-life screens were utilized in an effort to guide the structure-activity relationship in order to improve the pharmacokineti