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Improved deprotection in solid phase peptide synthesis: quantitative reduction of methionine sulfoxide to methionine during HF cleavage

✍ Scribed by James P. Tam; William F. Heath; R.B. Merrifield

Book ID
104220970
Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
277 KB
Volume
23
Category
Article
ISSN
0040-4039

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One-pot full peptide deprotection in Fmo
One-pot full peptide deprotection in Fmoc-based solid-phase peptide synthesis: methionine sulfoxide reduction with Bu4NBr
✍ Lorena Taboada; Ernesto NicolΓ‘s; Ernest Giralt πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 68 KB

The reduction of methionine sulfoxide with Bu 4 NBr in TFA is reported. The use of this reagent in conjunction with Fmoc chemistry-based acidolytic cocktails and the short reaction times that are needed for sulfoxide reduction (5 min) are the main advantages of this method, which is compatible with