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Improved delayed enhanced myocardial imaging with T2-Prep inversion recovery magnetization preparation

✍ Scribed by Chia-Ying Liu; Oliver Wieben; Jean H. Brittain; Scott B. Reeder

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
531 KB
Volume
28
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To develop a magnetization preparation method that improves the differentiation of enhancing subendocardial infarction (MI) from ventricular blood for myocardial delayed‐enhancement (DE) magnetic resonance imaging (MRI).

Materials and Methods

T~2~Prep‐IR is a magnetization preparation pulse that consists of a T~2~ preparation (T~2~Prep) followed immediately by a nonselective inversion recovery (IR) pulse. The first imaging excitation is then delayed an inversion time (TI) to allow nulling of normal myocardium in DE study. The amount of T~2~ contrast is determined by the effective echo time of the T~2~Prep pulse, TE~eff~. TE~eff~ is selected to differentiate MI and blood that share similar T~1~ values but have different T~2~ values. The T~2~Prep‐IR preparation was incorporated into a fast gradient echo sequence to produce an image with both T~1~ and T~2~ weighting. Simulations predict that this method will generate improved contrast between MI and chamber blood compared to conventional IR methods.

Results

Comparisons between images acquired using conventional IR and T~2~Prep‐IR in patients with MI indicate that this new approach significantly improves the blood‐MI contrast (122 ± 32% higher than that of IR with P < 0.05).

Conclusion

Our preliminary patient studies confirm that this preparation is helpful for improved delineation of subendocardial infarction. J. Magn. Reson. Imaging 2008;28:1280–1286. © 2008 Wiley‐Liss, Inc.

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