Improved chemotherapy for ovarian cancer with cis-diamminedichloroplatinum and adriamycin
โ Scribed by Howard W. Bruckner; Carmel J. Cohen; Judith D. Goldberg; Bernard Kabakow; Robert C. Wallach; Gunter Deppe; Ezra M. Greenspan; Saul B. Gusberg; James F. Holland
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 671 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0008-543X
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Combination chemotherapy with Adriamycin-cyclophosphamide was employed after surgical treatment in 60 women with Stage 111-IV ovarian adenocarcinoma. Of 53 evaluable patients, objective response was noted in 34 of 41 (83%) without prior cytotoxic therapy but in only two of 12 (17%) who had failed a
Fourteen patients with advanced head and neck carcinomas received a monthly intravenous regimen of Adriamycin, 40 mg/m2, day 1; cyclophosphamide, 400 mg/m2, day 3; and cis-diamminedichloroplatinum, 20 mg/m2/1 hour, days 1-3 (CAP-3). A regression rate of only 7% (0112 squamous cell carcinomas; 112 ad