Improved benefit/risk ratio of higher-dose metoclopramide therapy during cisplatin-induced emesis

Improved control of cisplatin-induced em

Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients

✍ Mark G. Kris; Richard J. Gralla; Leslie B. Tyson; Rebecca A. Clark; David P. Kel 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

A series of consecutive trials were undertaken to determine whether higher doses of intravenous metoclopramide and combinations of metoclopramide, dexamethasone, and diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/