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Importance of Tetrahedral Intermediate Formation in the Catalytic Mechanism of the Serine Proteases Chymotrypsin and Subtilisin

✍ Scribed by Petrillo, Teodolinda; O’Donohoe, Catrina A.; Howe, Nicole; Malthouse, J. Paul G.

Book ID
126276770
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
443 KB
Volume
51
Category
Article
ISSN
0006-2960

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## Abstract The effect of structural dynamics on enzyme activity and thermostability has thus far only been investigated in detail for the serine protease α‐chymotrypsin (for a recent review see Solá et al., Cell Mol Life Sci 2007, 64(16): 2133–2152). Herein, we extend this type of study to a struc