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Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases

✍ Scribed by Felipe Cortés; Joaquín Piñero; Trinidad Ortiz

Book ID
113255823
Publisher
Elsevier Science
Year
1993
Weight
741 KB
Volume
303
Category
Article
ISSN
0165-7992

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Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. In this study merbarone was used as a model compound to investigate the genotoxic effects of catalyt