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Importance of Glu-125 in the catalytic activity of human renal dipeptidase

✍ Scribed by Hideki Adachi; Toyoko Katayama; Hiroshi Nakazato; Masafumi Tsujimoto


Book ID
113269221
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
650 KB
Volume
1163
Category
Article
ISSN
0167-4838

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The importance of van der Waals contact between Glu 35 and Trp 109 to the active-site structure and the catalytic properties of human lysozyme (HL) has been investigated by site-directed mutagenesis. The X-ray analysis of mutant HLs revealed that both the replacement of Glu 35 by Asp or Ala, and the