✦ LIBER ✦

Importance of detection of ss-a/ro autoantibody in screening immunofluorescence tests for autoantibodies to nuclear antigens

✍ Scribed by Dr. David J. Bylund; Robert M. Nakamura

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 709 KB
Volume: 5
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860050311

No coin nor oath required. For personal study only.

✦ Synopsis

SS-A/Ro autoantibodies are related to Sjögren's syndrome and to several clinical subsets of lupus erythematosus. The most widely used laboratory procedure for ANA screening is the indirect immunofluorescence test (IF-ANA); the laboratory detection of anti-SS-A/Ro requires implementation and adherence to several technical and quality assurance recommendations. Using appropriate substrate cells containing the SS-A/Ro antigen, many so-called "ANA-negative" lupus erythematosus patients will demonstrate a positive IF-ANA.

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