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Importance of Ca 2+ -Dependent Transamidation Activity in the Protection Afforded by Tissue Transglutaminase against Doxorubicin-Induced Apoptosis †

✍ Scribed by Datta, Sunando; Antonyak, Marc A.; Cerione, Richard A.

Book ID
126235096
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
596 KB
Volume
45
Category
Article
ISSN
0006-2960

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The mechanism of the induction of apoptosis by arsenic trioxide (As 2 O 3 ), which was demonstrated recently to be an effective inducer of apoptosis in patients with leukemia, was examined in detail in human leukemia U937 cells. Upon treatment of U937 cells with 50 M of As 2 O 3 , complete inactivat