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Importance of 5 -Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer

✍ Scribed by Levesque, E.; Laverdiere, I.; Lacombe, L.; Caron, P.; Rouleau, M.; Turcotte, V.; Tetu, B.; Fradet, Y.; Guillemette, C.


Book ID
125987158
Publisher
American Association for Cancer Research
Year
2013
Tongue
English
Weight
545 KB
Volume
20
Category
Article
ISSN
1078-0432

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## Abstract In the prostate, the enzyme encoded by the __SRD5A2__ gene (5α‐reductase) converts testosterone to dihydrotestosterone, a potent androgen that has been hypothesized to play a role in the genesis of prostate cancer. Several polymorphisms have been identified in the __SRD5A2__ gene, inclu