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Implications of presenilin 1 mutations in Alzheimer’s disease

✍ Scribed by Hiroto Komano; Shinji Sudoh; Yuuki Kawamura; Rong Wang; Katsuhiko Yanagisawa

Book ID
114096642
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
324 KB
Volume
107
Category
Article
ISSN
0047-6374

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The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The