Implications of G-Protein-Mediated Ca2+ Channel Inhibition for Neurotransmitter Release and Facilitation
β Scribed by Richard Bertram; Matthew Behan
- Book ID
- 110271481
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 127 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0929-5313
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## Abstract Presynaptic Ξ³βaminobutyric acid type B receptors (GABA~B~Rs) regulate transmitter release at many central synapses by inhibiting Ca^2+^ channels. However, the mechanisms by which GABA~B~Rs modulate neurotransmission at descending terminals synapsing on motoneurons in the spinal cord rem
## Abstract **Background:** Rab3A, a member of the Rab3 small G protein family, regulates Ca^2+^βdependent exocytosis of neurotransmitter. The cyclical activation and inactivation of Rab3A are essential for the Rab3A action in exocytosis. GDPβRab3A is activated to GTPβRab3A by Rab3 GDP/GTP exchange