Implications of copy-number variation in the human genome: a time for questions
β Scribed by Daar, Abdallah S.; Scherer, Stephen W.; Hegele, Robert A.
- Book ID
- 109952360
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 114 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-0056
- DOI
- 10.1038/nrg1884
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## Abstract Highβresolution techniques for analysis of genome copy number (CN) enable the analysis of complex cancer somatic genetics. However, the analysis of these data is difficult, and failure to consider a number of issues in depth may result in false leads or unnecessary rejection of true pos
In the past few years the number of copy number variants (CNVs) identified in the human genome has increased significantly, but our understanding of the functional impact of CNVs is still limited. Clinically significant variations cannot easily be distinguished from benign, complicating interpretati