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Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen

✍ Scribed by Lamia Naouel Hachehouche; Nizar Chetoui; Fawzi Aoudjit

Book ID
116757660
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
313 KB
Volume
47
Category
Article
ISSN
0161-5890

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## Abstract Discoidin domain receptor 1 (DDR1) is a nonintegrin collagen receptor tyrosine kinase with an extracellular domain homologous to discoidin 1 of a soil‐living amoeba __Dictyostelium discoideum__. We have previously demonstrated that DDR1 mediates collagen‐induced nitric oxide production

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## Abstract Discoidin domain receptor I **(**DDR1) is a receptor tyrosine kinase (RTK) and serves as the receptor for collagen in addition to integrins. It has been well established that Madin–Darby canine kidney (MDCK) cells develop branching tubules in three‐dimensional collagen gel in the presen