If a linear relationship exists between the rate of drug release or dissolution in the gastrointestinal tract, f ( t ) , and the resulting systemic drug level, c(t), that relationship can be expressed as a convolution: where c&) is the systemic drug concentration resulting from the instantaneous in
โฆ LIBER โฆ
Implication of biopharmaceutics and pharmacokinetics of rifampicin in variable bioavailability from solid oral dosage forms
โ Scribed by Shrutidevi Agrawal; Ramesh Panchagnula
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 160 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.464
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## Abstract The bioavailability and pharmacokinetics of two hydrochlorothiazide products were compared following single 50 mg oral doses to 20 healthy male volunteers. Plasma and urine were assayed for hydrochlorothiazide by a specific and sensitive HPLC method. Plasma profiles of hydrochlorothiazi