EXPERIMENTAL PROCEDURES A N D RESULTS ## Procedures Covalent addition of biotin to primary amino groups of polypeptides occurs by the condensation reaction shown in Figure 1.
Implantable pumps for drug delivery to the brain
โ Scribed by Sanjay Bakhshi; Richard B. North
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 646 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0167-594X
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Implantable drug delivery systems formulated from drug-polymer composites have been used recently in a variety of applications in which chronic administration of a pharmacological agent to a specific anatomic site is advantageous. These drug delivery systems are generally referred to as controlled r
The blood-brain barrier (BBB) limits the transport of therapeutic molecules from the blood compartment into the brain, thus greatly reducing the species of therapeutic compounds that can be efficiently accumulated in the central nervous system (CNS). Various strategies have been proposed for improvi