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IMPDH activity in thiopurine-treated patients with inflammatory bowel disease – relation to TPMT activity and metabolite concentrations

✍ Scribed by Sofie Haglund; Jan Taipalensuu; Curt Peterson; Sven Almer

Book ID
108641926
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
681 KB
Volume
65
Category
Article
ISSN
0306-5251

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Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well kno