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Impairment of NK Cell Function by NKG2D Modulation in NOD Mice

✍ Scribed by Kouetsu Ogasawara; Jessica A Hamerman; Honor Hsin; Shunsuke Chikuma; Helene Bour-Jordan; Taian Chen; Thomas Pertel; Claude Carnaud; Jeffrey A Bluestone; Lewis L Lanier

Book ID: 117723318
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 646 KB
Volume: 18
Category: Article
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(02)00505-8

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## Abstract Herein, we show that γδT, CD8^+^αβT lymphocytes and natural killer (NK) cells display a different sensitivity to survival signals delivered __via__ NKG2D surface receptor. All the three effector cell populations activate Akt1/PKBalpha through the engagement of this molecule. Upon bindin