Regulation of human liver δ-aminolevulin
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Anne-Kathrin Peyer; Diana Jung; Markus Beer; Carmela Gnerre; Adrian Keogh; Debor
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Article
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2007
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John Wiley and Sons
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English
⚖ 660 KB
Aminolevulinic acid synthase 1 (ALAS1) is the rate-limiting enzyme of heme synthesis in the liver and is highly regulated to adapt to the metabolic demand of the hepatocyte. In the present study, we describe human hepatic ALAS1 as a new direct target of the bile acid-activated nuclear receptor farne