Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia–lymphoma cell lines with microsatellite instability

Aberrant splicing of the ATM gene associ

Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: A novel mutation target of microsatellite instability

✍ Yosuke Ejima; Lichun Yang; Masao S. Sasaki 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 181 KB 👁 2 views

Inherited mutations of the ATM gene are responsible for the human autosomal recessive disorder ataxia-telangiectasia (A-T) characterized by pleiotropic clinical manifestations. ATM mutations are also involved in the development of sporadic human cancers such as T-cell prolymphocytic leukemia and B-c