✦ LIBER ✦
Impairment of conditioned active avoidance in adult rats given corticosterone in infancy
✍ Scribed by Dr. David S. Olton; Craig T. Johnson; Evelyn Howard
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 385 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0012-1630
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum. After such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks. In comparison with litter‐mate controls, the treated rats were impaired in the acquisition of 2‐way active avoidance but not in the acquisition of 1‐way active avoidance. These data are consistent with other observations suggesting a hyperresponsiveness or hyperemotionality following corticosterone treatment in infancy.