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Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance

✍ Scribed by Akira Kuroe; Mitsuo Fukushima; Masaru Usami; Masaki Ikeda; Yoshikatsu Nakai; Ataru Taniguchi; Toshifumi Matsuura; Haruhiko Suzuki; Takeshi Kurose; Koichiro Yasuda; Yuichiro Yamada; Yutaka Seino


Book ID
117370594
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
334 KB
Volume
59
Category
Article
ISSN
0168-8227

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Recent evidence suggests that the postprandial hyperglycaemia in impaired glucose tolerance is primarily due to impaired suppression of basal hepatic glucose output. This in turn appears to be secondary to decreased first phase insulin secretion, although decreased hepatic insulin sensitivity, which