Impaired T-cell stimulation by antigen-presenting cells results from defective accessory cell function in HLA-B27 transgenic rat
✍ Scribed by G Falgarone, C Hacquard-Bouder, A Bosquet, D Monnet, M Breban
- Book ID
- 120707979
- Publisher
- BioMed Central
- Year
- 2003
- Tongue
- English
- Weight
- 595 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar699
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## Abstract ## Objective A disease resembling the human spondylarthropathies develops in HLA–B27–transgenic rats. This disease in rats is mediated by CD4+ T cells, but antigen‐presenting cells (APCs) may also play a role. Dendritic cells (DCs) have been reported to be defective in allogeneic mixed
## Abstract ## Objective To investigate the molecular mechanism responsible for the reduced capacity of dendritic cells (DCs) from HLA–B27–transgenic rats to form conjugates with naive T cells. ## Methods We monitored interactions between DCs derived from HLA–B27–transgenic, HLA–B7–transgenic co