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Impaired repair of DNA double strand breaks in genetically unstable cell lines of malignant melanoma and tumorigenic keratinocytes

✍ Scribed by Diem, C.; Kotas, M.; Tzung, T.Y.; Leverkus, M.; Möller, K.; Rünger, T.M.

Book ID: 119562074
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 206 KB
Volume: 16
Category: Article
ISSN: 0923-1811
DOI: 10.1016/s0923-1811(98)83293-3

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## Abstract Abnormal activation of cellular DNA repair pathways by deregulated signaling of receptor tyrosine kinase systems has broad implications for both cancer biology and treatment. Recent studies suggest a potential link between DNA repair and aberrant activation of the hepatocyte growth fact