𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Impaired release of vitamin a from liver in primary biliary cirrhosis

✍ Scribed by Anders Nyberg; Berit Berne; Hans Nordlinder; Christer Busch; Ulf Eriksson; Lars Lööf; Anders Vahlquist

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
671 KB
Volume
8
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

In 44 patients with primary biliary cirrhosis serum levels of vitamin A, retinol-binding protein and transthyretin (prealbumin) were found to be significantly lower than in 25 sex-and age-matched controls. Liver biopsies were available for chemical analyses in 28 of the patients. Their mean liver vitamin A concentration (2.8 f 2.0 fimoles per gm wet weight) did not differ significantly from that in 22 cases of sudden death which served as controls (2.0 f 1.5 fimoles per gm wet weight). Immunohistochemical investigation showed a normal distribution of serum retinol-binding protein in the patients' livers, whereas the staining pattern of cellular retinol-binding protein, believed to be involved in the intrahepatic transport of vitamin A, was abnormal. Thus, the number size and cellular retinol-binding protein staining intensity of fat-storing (Ito) cells were clearly higher in the patients as compared with controls. The results suggest that the low serum vitamin A levels in primary biliary cirrhosis are not a consequence of vitamin A deficiency but instead reflect a defective mobilization of vitamin A from the liver.

📜 SIMILAR VOLUMES

Vitamin A and zinc therapy in primary bi
Vitamin A and zinc therapy in primary biliary cirrhosis
✍ H. Franklin Herlong; Robert M. Russell; Willis C. Maddrey 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB 👁 1 views

Eleven patients with primary biliary cirrhosis were surveyed for evidence of vitamin A and zinc deficiencies. Vitamin A deficiency manifested as a low serum vitamin A concentration and abnormal dark adaptation was present in 9 of the 11 patients. A low serum zinc level was present in four patients w

Does Primary Biliary Cirrhosis in Men Di
Does Primary Biliary Cirrhosis in Men Differ from Primary Biliary Cirrhosis in Women?
✍ Lawrence R. Rubel; Lionel Rabin; Leonard B. Seeff; Harvey Licht; Brenda A. Cucch 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 848 KB

Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitoch

Eosinophilic infiltration of the liver i
Eosinophilic infiltration of the liver in primary biliary cirrhosis: A morphological study
✍ Shuichi Terasaki; Yasuni Nakanuma; Masakazu Yamazaki; Masashi Unoura 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 859 KB

Eosinophils and their secretory proteins are important in necroinflammatory processes. In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary biliary cirrhosis. A considerable number of eosinophils were found in the portal tracts in

Optimal timing of liver transplantation
Optimal timing of liver transplantation for primary biliary cirrhosis
✍ W. Ray Kim; Russell H. Wiesner; Terry M. Therneau; John J. Poterucha; Michael K. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 2 views

In 1989, we reported on the efficacy of liver transplantation in primary biliary cirrhosis (PBC) by demonstrating that the actual patient survival following transplantation was significantly better than without transplantation as predicted by a mathematical survival model ("Mayo natural history mode

Kinetics of 64copper in primary biliary
Kinetics of 64copper in primary biliary cirrhosis
✍ A. Roelof Janssens; Cornelis J. A. Van Den Hamer 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 673 KB

To assess the pathogenetic mechanisms involved in the accumulation of copper in primary biliary cirrhosis (PBC), the kinetics of 64Copper ("Cu) were studied in 6 healthy volunteers, 3 patients with PBC (Stages I to 111) and a normal liver copper, and 7 patients with PBC (Stages I1 to IV) and a high