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Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice

✍ Scribed by Hiruma, Yoshiharu; Tsuda, Eisuke; Maeda, Naoyuki; Okada, Akiko; Kabasawa, Noriko; Miyamoto, Megumi; Hattori, Hiroyuki; Fukuda, Chie


Book ID
120832970
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
758 KB
Volume
53
Category
Article
ISSN
8756-3282

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## Abstract The role of osteopontin in bone resorption was elucidated by studies of mice with knock out of the osteopontin gene generated by a different approach compared to previous models. Thus, a targeting vector with the promoter region as well as exons 1, 2, and 3 of the osteopontin gene was r