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Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

✍ Scribed by Ryuichi Amakawa; Anne Hakem; Thomas M Kundig; Toshifumi Matsuyama; John J.L Simard; Emma Timms; Andrew Wakeham; Hans-Willi Mittruecker; Henrik Griesser; Hiroaki Takimoto; Rudolf Schmits; Arda Shahinian; Pamela S Ohashi; Josef M Penninger; Tak W Mak


Book ID
117267927
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
302 KB
Volume
84
Category
Article
ISSN
0092-8674

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A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal Hodgkin/Reed-Sternberg cells, but also in a fraction of morphologically normal cells. However, the phenotypic constitution of these genetically abnormal, morpho