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Impaired intestinal tolerance in the absence of a functional complement system

✍ Scribed by Pekkarinen, Pirkka T.; Vaali, Kirsi; Jarva, Hanna; Kekäläinen, Eliisa; Hetemäki, Iivo; Junnikkala, Sami; Helminen, Merja; Vaarala, Outi; Meri, Seppo; Arstila, T. Petteri

Book ID
121891711
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
661 KB
Volume
131
Category
Article
ISSN
1097-6825

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A critical role for complement in the regulation of self tolerance has been proposed to explain the strong association between complement deficiency and autoimmunity. To elucidate the role of the classical pathway of complement in the maintenance of B cell tolerance, C1qdeficient (C1qa-/-) mice were