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Impaired in vivo dopamine release in parkin knockout mice

✍ Scribed by Genko Oyama; Kenji Yoshimi; Shihoko Natori; Yoko Chikaoka; Yong-Ri Ren; Manabu Funayama; Yasushi Shimo; Ryosuke Takahashi; Taizo Nakazato; Shigeru Kitazawa; Nobutaka Hattori

Book ID
113505107
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
863 KB
Volume
1352
Category
Article
ISSN
0006-8993

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## Abstract __Parkin__ is the causal gene of autosomal recessive juvenile parkinsonism (AR‐JP). Dopamine (DA) metabolism has been linked to Parkinson's disease (PD). To understand the pathogenesis of AR‐JP, we generated parkin‐deficient mice to assess the status of DA signaling pathway and examine