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Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin-1 in Rheumatoid Arthritis

✍ Scribed by Eric F. Morand; Carolyn M. Jefferiss; Jonathan Dixey; Devashis Mitra; Nicolas J. Goulding


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
482 KB
Volume
37
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)