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Impaired expression of hypoxia-inducible factor-1α in cystic fibrosis airway epithelial cells – A role for HIF-1 in the pathophysiology of CF?

✍ Scribed by Claire Legendre; Marlies J. Mooij; Claire Adams; Fergal O'Gara

Book ID
119288835
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
390 KB
Volume
10
Category
Article
ISSN
1569-1993

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## Abstract Focal adhesion kinase (FAK) and hypoxia‐inducible factor (HIF‐1α) are both up‐regulated in glioblastoma multiforme (GBMs), particularly in invasive zones. Because FAK may play an important role in the invasion of glioma cells into the surrounding brain, we sought an agent that causes do