Impaired cytolytic activity in peripheral blood T cells from renal cell carcinoma patients
β Scribed by Todd S. Crocenzi; Christopher P.G. Tretter; Thomas Schwaab; Alan R. Schned; John A. Heaney; Bernard F. Cole; Jan L. Fisher; Marc S. Ernstoff
- Book ID
- 116366373
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 144 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1090-2341
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Dendritic cells are considered to be the initiators of immune responses, including those directed against tumors. Clinical research on dendritic cells was long hampered by the limited availability of these cells. The recent identification of cytokine combinations that mobilize dendritic cells with p
TIL were cultured from human renal-cell carcinoma (RCC) in 1,000 U/ml rlL2 and restimulated with autologous tumor in efforts to establish which conditions would best expand the number of lymphocytes cytotoxic for autologous tumor. Greater cell yields resulted from multiple restimulations of TIL with