Impaired cytokine production in whole blood cell cultures from patients with colorectal carcinomas as compared to benign colorectal tumors and controls
✍ Scribed by U. Elsässer-Beile; S. von Kleist; R. Fischer; J. Schulte Mönting
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 405 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0887-8013
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✦ Synopsis
Cytokine production was investigated in whole blood cell cultures from 74 patients with colorectal carcinomas, 20 patients with benign colorectal tumors, and 31 4 healthy controls. In the 4 day post induction supernatants the levels of IFN-gamma, 11-1 -alpha, 11-2, and TNF-alpha were measured by a sensitive immunoassay.
In the blood cell cultures of the patients with colorectal carcinomas significantly lower values of IFN-gamma (P s .001), 11-1 -alpha (P s .001), and IL-2 (P 4.01) were found as com-pared to the patients with benign tumors and the controls, although total and differential leukocyte counts were similar in all three groups. A linear correlation between the levels of IFNgamma and IL-1-alpha and the tumor stages could be shown.
Our results suggest that a growing tumor burden may induce increasing immunological deficiencies as reflected by a decreasing cytokine production of the immune cells.