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Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing

โœ Scribed by Rajeshwari Medicherla; Susan Leers-Sucheta; Ya Luo; Salman Azhar


Book ID
114096040
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
216 KB
Volume
122
Category
Article
ISSN
0047-6374

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Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1