## Abstract We have previously reported that connexin (Cx) 32 gene, a member of gap junctions, was specifically downregulated in human renal cell carcinoma (RCC) and it acts as a tumor suppressor against RCC. Because there is no standard therapy for advanced RCC, we investigated the antiβmetastatic
Impact of tyrosine kinase inhibitors on the incidence of brain metastasis in metastatic renal cell carcinoma
β Scribed by Jonathan Verma; Eric Jonasch; Pamela Allen; Nizar Tannir; Anita Mahajan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 382 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background We investigated the effects of vandetanib, an inhibitor of vascular endothelial growth factor receptor 2 (VEGFRβ2) and epidermal growth factor receptor (EGFR), alone and in combination with paclitaxel in an orthotopic mouse model of human head and neck squamous cell carci
Breast cancers frequently over-express a number of growth factor receptors. In addition, elevated src family kinase activity is present in a percentage of these neoplasms and has been implicated in signal transduction in these cells. Therefore, inhibiting tyrosine kinase activity is a potential appr
## Abstract ## BACKGROUND: Sunitinib has replaced interferon (IFN) as a firstβline standard of care in the treatment of metastatic renal cell carcinoma (RCC). This study aimed to determine overall survival and to confirm effectiveness in a population that includes poor prognosis patients. ## METH