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Impact of the tumor microenvironment on host infiltrating cells and the efficacy of flt3-ligand combination immunotherapy evaluated in a treatment model of mouse prostate cancer

✍ Scribed by Richard P. Ciavarra; Roy R. Brown; Daniel A. Holterman; Marianne Garrett; William F. Glass; George L. Wright; Paul F. Schellhammer; Kenneth D. Somers

Publisher: Springer-Verlag
Year: 2003
Tongue: English
Weight: 790 KB
Volume: 52
Category: Article
ISSN: 0340-7004
DOI: 10.1007/s00262-003-0383-x

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## Abstract We established an orthotopic treatment model of prostate cancer to generate reproducible primary and metastatic carcinoma in immunocompetent C57BL/6 mice. Using an __in vivo__ selection scheme of intraprostatic implantation of TRAMP‐C1 cells, primary prostate tumors were cultured and re