Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas

✍ Scribed by H. J. Cho; M. Seiberg; I. Georgoff; A. K. Teresky; J. R. Marks; A. J. Levine

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 845 KB
• Volume: 24
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490240116

✦ Synopsis

Transgenic mice harboring the SV40 large T antigen gene in a C57B1/6J genetic background (SV11) first express this gene at 1-2 weeks of age, develop papillomas of the choroid plexus by 80-90 days, and die within 125 days after birth. Transgenic mice harboring the same transgene in a (SVll-C57B1/6J X NZW/ lacJ) F1 genetic background express considerably lower levels of the transgene mRNA at comparable times after birth. As a consequence, tumor development and death are delayed. The NZW mice appear to contribute a dominant negative regulator for the expression of the SV40 large T antigen transgene, which in turn has a dramatic effect upon the time of appearance of tumors and the death of these transgenic animals.