✦ LIBER ✦

Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults

✍ Scribed by Dr. Jeanna L. Welborn

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 378 KB
Volume: 45
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830450413

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The clinical outlook for adults with acute lymphoblastic leukemia (ALL) has Improved with the use of intensive chemotherapy. Complete remissions (CR) are achieved in 80% of adults but the majority relapse on maintenance chemotherapy and a few exhibit primary resistance to induction therapy. This report compares the various salvage treatments and provides guidance in selecting a regimen with the optimum clinical outcome. Regimens using high‐dose ara‐C (HDAC) in combination with mltoxantrone, amsacrine, or idarublcin are superior to HDAC alone or with L‐asparaginase. The sequential administration of methotrexate and L‐asparaginase Is equally effective. The duration of second CR is short for all chemotherapeutic regimens. © 1994 Wiley‐Liss, Inc.

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