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IMPACT OF RECOMBINANT FACTOR VIII! ON HEMOPHILIA CARE

✍ Scribed by PIER MANNUCCIO MANNUCCI

Book ID
115110177
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
303 KB
Volume
67
Category
Article
ISSN
0042-9007

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Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice
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Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg