Impact of peginterferon alpha-2b and ribavirin treatment on liver tissue in patients with HCV or HCV–HIV co-infection
✍ Scribed by Rui Sarmento-Castro; Ana Horta; Olga Vasconcelos; Helena Coelho; Josefina Mendez; Ana Paula Tavares; João Seabra; Manuela Duarte; Leonor Chaves; Olga Fortes; Cristina Recalde; Ângela Ventura; Nuno Pires; Luciana Pinho; Nancy Dias; Fátima Carneiro
- Book ID
- 108174454
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 205 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0163-4453
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We sought to validate FIB-4 using data retrospectively collected from treatment-naive HIV/HCV patients. The original model was adapted in order to use AST and ALT levels expressed as times the upper limit of normality (ϫULN), as follows: (age [yr] ϫ AST [ϫULN]) ϫ 10/((PLT [10 9 /l]) ϫ (ALT [ϫULN]) 1
## Abstract A study was carried out to determine whether early viral dynamics retain prediction of the outcome of peginterferon (PEG‐IFN) and ribavirin combination therapy based on different genetic polymorphisms near the __IL28B__ gene, the strongest baseline predictor of response to this therapy.
The IL28B genotype is the most important pretreatment predictor of treatment outcome in patients with chronic hepatitis C. The impact of the rs12979860 genotype on relapse was retrospectively evaluated in genotype 1/4 patients who received response-guided therapy with peginterferon alpha-2a 180 μg/w